Jocelyne Bachevalier

Professor of Psychology

Office: 397 Psychology Building

Phone: 404-727-9765

Fax: 404-727-0372

Email: jbachev@emory.edu

Additional Contact Information

Mailing Address:

Department of Psychology

Emory University
36 Eagle Row

Atlanta, GA 30322

Biography

Dr. Bachevalier received a Doctorate Degree in Psychophysiology from the University of Paris in 1975 and a Ph. D. in Clinical Sciences from the University of Montreal in 1981. She was a Visiting Scientist at the National Institute of Mental Health in Bethesda (MD) until 1991 and then took a position of Professor in Neurobiology and Anatomy at the University of Texas-Houston. She joined the Emory faculty in Summer, 2004.

People

  1. Lab Members:
    1. Maria Alvarado, Ph.D., Assistant Research Professor
    2. Anne-Pierre Goursaud, Ph.D., Guest Researcher
    3. Rebecca Richardson, Lead Research Specialist
    4. Anthony Gazy, Research Assistant
  2. Postdoctoral Fellows:
    1. Andy Kazama, PhD
    2. Christa Payne, PhD
    3. Jessica Raper, PhD
  3. Graduate Students:
    1. Emily Johnson
    2. Alison Weiss
  4. Undergraduate Students:
    1. Jordan Johnston, Preparatory Research Experience (PREP) post-baccalaureate Program
    2. Clara Wynn
    3. Ava Tompkins
    4. Madison Klavans
  5. Former Postdoctoral Fellows and Students:
    1. Mario Beauregard, Ph.D., postdoctoral fellow now an Associate Researcher in the Departments of Psychology and Radiology and the Neuroscience Research Center at the University of Montreal, Canada. Recent book: The Spiritual Brain: A neuroscientist’s case for the existence of the Soul (HarperCollins).
    2. Olivier Pascalis, Ph.D., postdoctoral Fellow now a CNRS Researcher in the “Laboratoire de Psychologie et Neurocognition” at the “Université Pierre Mendes France” (Grenoble, France).
    3. Maria Alvarado, Ph.D., postdoctoral Fellow now Assistant Research Professor at the Yerkes National Primate Research Center, Emory University, Atlanta.
    4. Sarah Nemanic, Ph.D., graduate student now Doctor in Veterinary Medicine and Diagnostic Imaging Resident at the Michigan State University.
    5. Christopher Machado, Ph.D., graduate student now an Adjunct Professor in the Department of Psychiatry at University of California-Davis.
    6. Eugena Mitchell, Ph.D., graduate student now a Postdoctoral Fellow in the Department of Psychology at the University of Minnesota.
    7. Alyson Zeamer, Ph.D., graduate student now a Postdoctoral Fellow in the Department of Anatomy at Thomas Jefferson University-Philadelphia.
    8. Courtney-Glavis Bloom, Ph.D., graduate student now a Postdoctoral Fellow at SRI International, Mento Park, Ca.

Research

  1. Research Program: Our laboratory investigates the neural substrates underlying the development of learning and memory functions, and the regulation of socioemotional behaviors in nonhuman primates. An important facet of our research program has been to relate basic findings in nonhuman primates to normal development of cognitive functions in children and to abnormal human behavior, such as autism, schizophrenia, and anxiety disorders.  Our studies use a combination of newly designed behavioral tasks to test episodic-like memory processes, decision-making abilities and emotional regulation in infant and adult monkeys as well as observations of social skills in semi-naturalistic environment, selective MRI-guided neurotoxic lesions and neurochemical deactivations, and neuroimaging techniques (structural MRI, Diffusion Tensor Imaging, and Spectroscopy) and neuroanatomical procedures to assess brain reorganization following neonatal brain lesions.

  2. Current studies:
  • The development of medial temporal lobe functions: This project investigates the role of different medial temporal structures and their interactions with the prefrontal cortex in episodic-like memory processes in the adult monkeys and assesses how the maturational time course of these brain areas map onto the development of these memory processes from infancy through adulthood. 
  • Safety signal learning in monkeys: cortical regulation and its development: This collaborative project with Dr. Michael Davis (YNPRC) is an attempt to modify our existing fear inhibition paradigm to permit its use longitudinally, first to investigate (pre- and post-surgery) which specific orbital frontal sectors are involved in the acquisition and expression of conditioned inhibition (safety signal learning) in male and female adult monkeys and second follow longitudinally when orbital frontal regulation of conditioned inhibition emerged in primates of both sexes. 
  • Amygdala: sex differences in behavior, cognition and neuroendocrine development: This collaborative with Drs Kim Wallen and Mar Sanchez  investigates social, emotional, cognitive and neuroendocrine consequences of neonatal and post-pubertal amygdalectomy in male and female rhesus monkeys living in semi-natural complex social groups.
  • Hippocampal-Prefrontal Control of Working Memory: Inactivation and PET in Monkeys:  This study, headed by Dr. Maria Alvarado, combines pharmacological inactivation, PET imaging and neuroanatomical tracers to directly assess whether hippocampal modulation of dorsolateral PFC function occurs via the meso-limbic dopamine system (a circuit including the nucleus accumbens, ventral pallidum and ventral tegmental area (VTA)) in nonhuman primates

Publications

Kazama AM, Bachevalier J (2012) Preserved stimulus-reward and reversal learning after selective neonatal orbital frontal areas 11/13 or amygdala lesions in monkeys.Developmental Cognitive Neuroscience. 2(3):363-80.

Kazama AM, Heuer E, Davis M, Bachevalier J (2012) Effects of neonatal amygdala lesions on fear learning, conditioned inhibition and extinction in adult macaques.Behavioral Neuroscience. 126(3):392-403.

Paul MG, Green L, Myerson J, Alvarado M, Bachevalier J, Schneider JS, Cory-Slechta DA, Schantz SL (2012) Behavioral Toxicology of Cognition: Extrapolation from Experimental Animal Models to Humans Behavioral Toxicology Symposium Overview,Neurotoxicology and Teratology.34(2):263-73.

Jovanovic T, Kazama A, Bachevalier J, Davis M (2012) Lack of safety signal learning may be a biomarker of PTSD. Neuropharmacology, 62(2):695-704.

Bachevalier J, Machado C, Kazama A (2011) Behavioral outcomes of late-onset or early-onset orbital frontal cortex (areas 11/13) lesions in rhesus monkeys.  Annals of the New York Academy of Science. 1239:71-86.

Heuer E, Bachevalier J (2011) Neonatal hippocampal lesions in rhesus macaques alter the monitoring but not maintenance of information in working memory. Behavioral Neuroscience. 125(6):859-70.

Ewing-Cobbs L, Prasad MR, Swank P. Kramer L, Treble A, Payne C, Bachevalier J (in press) Social responsiveness and initiation in young children with traumatic brain injury: Relations with corpus callosum morphology.  International Journal of Developmental Neuroscience. 30(3):247-54.

Zeamer A, Meunier M, Bachevalier J (2011) Stimulus similarity and encoding time influence incidental recognition memory in adult monkeys with selective hippocampal lesions. Learning & Memory, 18: 170-180.

Heuer E, Bachevalier J (2011) Effects of selective neonatal hippocampal lesions on tests of object and spatial recognition memory in monkeys. Behavioral Neuroscience, 125:137-149.

Zeamer A, Heuer E, Bachevalier J (2010) Developmental trajectory of object recognition memory in infant rhesus monkeys with and without neonatal hippocampal lesions. Journal of Neuroscience, in press.

Alvarado M, Kazama A, Zeamer A, Bachevalier J (2010) The effects of selective hippocampal damage on tests of oddity in rhesus macaques. Hippocampus, in press.

Payne C, Machado CJ, Bliwise N, Bachevalier J (2009) Maturation of the hippocampal formation and amygdala in Macaca mulatta: A volumetric MRI study.  Hippocampus, 20:922-935.

Pascalis O, Hunkin NM, Bachevalier J, Mayes AR (2009) Change in background context disrupts performance on visual paired comparison following hippocampal damage. Neuropsychologia, 47:2107-2113.

Kazama A, Bachevalier J (2009) Selective aspiration or neurotoxic lesions of orbital frontal areas 11 and 13 spared monkey’s performance on the object discrimination reversal task. Journal of Neuroscience, 29: 2794-2804.

Machado C, Kazama A, Bachevalier J (2009) Impact of amygdala, orbital frontal or hippocampal lesions on threat avoidance and emotional reactivity in nonhuman primates, Emotions, 9:147-163.

Machado CJ, Bachevalier J (2008) Behavioral and hormonal reactivity to threat: Effects of selective amygdala, hippocampal or orbital frontal lesions in monkeys.Psychoneuroendocrinology. 33:926-941.

Loveland KA, Bachevalier J, Pearson DA, Lane DM (2008) Fronto-limbic Functioning in Children and Adolescents With and Without Autism. Neuropsychologia, 46:49-62.

Bachevalier J, Nemanic S (2008) Spatial memory in monkeys as measured with the visual paired-comparison task: effects of selective hippocampal, perirhinal and areas TH/TF lesions. Hippocampus, 18:64-80.

Machado CJ, Bachevalier J (2007) Measuring reward assessment in a semi-naturalistic context: The effects of selective amygdala, orbital frontal or hippocampal lesions.Neuroscience, 148:599-611.

Machado CJ, Bachevalier J (2007) The effects of selective amygdala, orbital frontal cortex or hippocampal formation lesions on reward assessment in nonhuman primates,European Journal of Neuroscience, 25: 2885-2904.

Wilde EA, Bigler ED, Hunter JV, Fearing MA, Scheibel RS, Newsome MR, Johnson JL, Bachevalier J, Li X, Levin HS (2007) Hippocampal, Amygdala and Basal Ganglia Morphometrics in Children after Moderate to Severe Traumatic Brain Injury.Developmental Medicine and Child Neurology, 49:294-299.

Goursaud A-P, Bachevalier J (2006) Social attachment in juvenile monkeys with neonatal lesion of the hippocampus, amygdala and orbital frontal cortex, Behavioral Brain Research, 176:75-93.

Meunier M, Cirilli L, Bachevalier J (2006) Responses to affective stimuli in monkeys with entorhinal and perirhinal cortex lesions.  Journal of Neuroscience, 26:7718-7722.

Bachevalier J, Malkova L  (2006) The amygdala and development of social cognition: Theoretical comments on Bauman, Toscano, Mason, Lavenex and Amaral (2006). Behavioral Neuroscience, 120: 989-991.

Machado CJ, Bachevalier J (2006) The impact of selective amygdala, orbital frontal cortex or hippocampal formation lesions on established social relationships in monkeys.Behavioral Neuroscience, 120:761-786.

Bachevalier J, Loveland K  (2006) The orbitofrontal-amygdala circuit and self-regulation of social-emotional behavior in autism. Neuroscience and Biobehavioral Reviews, 30:97-117.

Ewing-Cobbs K, Hasan KM, Prasad MR, Kramer L, Bachevalier J (2006) Relation of corpus callosum diffusion anisotrophy in neuropsychological outcomes in twins disconcordant for traumatic brain injury.  American Journal of Radiology, 27: 879-881.

Bachevalier J, Vargha-Khadem F (2005) The primate hippocampus: ontogeny, early insult and memory.  Current Opinion in Neurobiology, 15:168-174.